Lower Vitamin D Levels are Associated with Higher Seroprevalence of Toxoplasma gondii—a US National Survey Study

Objective: Vitamin D deficiency is associated with high susceptibility to infections. The present study aimed at exploring the relationship between vitamin levels and Toxoplasma gondii ( T. ) infection, on basis of a nationally representative database. Methods: data came from National Health Nutrition Examination Surveys (NHANES) 2001–2004. Participants underwent both IgG antibody testing serum testing. was defined by 25-hydroxyvitamin level <20 ng/mL. Multivariate logistic regression propensity score matching were used adjust for potential confounders. All analyses conducted in R software. Results: A total 10613 participants included. Among these, 3973 (37.4%) deficient, 2070 (19.5%) seropositive antibody. found 42.3% population, compared 36.3% seronegative population P <0.001). After adjustment sex, age, body mass index, smoking history, drinking history season, an elevated risk infection (OR=1.303, 95% CI=1.136–1.495, This effect persisted cohort. Conclusions: Low are seroprevalence .